Mendrisio is easily reachable from both Lugano and Milan Malpensa airport. For international travellers Milan Malpensa is likely to be more practical due to more direct connections. There is a Shuttle bus that will take you from Milan Malpensa to Mendriso. You will need to make an online reservation for this.
Train enthusiasts may wish to fly to Zurich and get the train to Mendrisio through the longest train tunnel in the world. The station is a short (11 min) walk from the Hotel. See map below.
Mendrisio has its own motorway exit of the A2 that goes from the Italian border in Chiasso north towards the Gotthard and Zurich. Follow signs for Mendrisio as you come off the motorway and at the second round about, take the first exit for the hotel.